TitleThe pore-forming bacterial effector, VopQ, halts autophagic turnover.
Publication TypeJournal Article
Year of Publication2013
AuthorsSreelatha, A, Orth, K, Starai, VJ
JournalAutophagy
Volume9
Issue12
Pagination2169-2170
Date Published2013 Dec 1
ISSN1554-8635
Abstract

Vibrio parahemolyticus Type III effector VopQ is both necessary and sufficient to induce autophagy within one hour of infection. We demonstrated that VopQ interacts with the Vo domain of the conserved vacuolar H(+)-ATPase. Membrane-associated VopQ subsequently forms pores in the membranes of acidic compartments, resulting in immediate release of protons without concomitant release of lumenal protein contents. These studies show how a bacterial pathogen can compromise host ion potentials using a gated pore-forming effector to equilibrate levels of small molecules found in endolysosomal compartments and disrupt cellular processes such as autophagy.

DOI10.4161/auto.26449
Alternate JournalAutophagy
PubMed ID24145145
Grant ListR01 AI100913 / AI / NIAID NIH HHS / United States
Department Authors: 
Vincent J. Starai
Lab Association: 
Starai
Research Areas: 
Molecular Microbiology
Microbial Physiology
Microbe-Host Interactions