Our laboratory is interested in bacterial metabolism and physiology. Much of the work we do is performed in Salmonella enterica because we can do sophisticated genetic analyses of strains. We are currently focused on three areas of research. First, we study metabolic pathway integration. We identified the cobB gene of Salmonella enterica as a new member of the SIR2 family regulatory proteins in eukaryotes whose activities are needed for gene silencing and cell aging. Our report was an important contribution to this field of research and led to the identification of two enzymatic activities associated with these proteins.