Yeqi joined the Lin lab in 2021 as a postdoctoral associate. He received a Ph.D degree from the Nanjing Normal University. His previous work mainly focuses on the drug resistance in Aspergillus fumigatus. Now his project involves in how the cryptococcus promotes host protective immune response. He is exploring which antigens presented in the cryptococcal cells and how to use these antigens or filamentous strains as vaccine candidates. With these works, he hopes to unravel the molecular mechanisms of antigens providing the protective effect.
1. Li Y, Pham T, Xie X, Lin X. Identification and characterization of an intergenic “safe haven” region in human fungal pathogen Cryptococcus gattii. J. Fungi 2022, 8, 178.
2. Li Y, Dai M, Lu L. The sterol C-14 reductase Erg24 is responsible for ergosterol biosynthesis and ion homeostasis in Aspergillus fumigatus. Appl Microbiol Biotechnol. 2021. 105:1253-1268
3. Li Y, Zhang Y, Zhang C, Wang H, Wei X, Chen P, Lu L. Mitochondrial dysfunctions trigger the calcium signaling dependent fungal multidrug resistance. Proc Natl Acad Sci U S A. 2020. 117 (3), 1711-1721
4. Li Y, Zhang Y, Lu L. Calcium signaling pathway is involved in non-CYP51 azole resistance in Aspergillus fumigatus. Med Mycol. 2019. 1;57 (Supplement_2): S233-S238.